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-synuclein, which can be a main element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which happens to be an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) pressure, suggest that dysfunction with the intracellular proteinase devices, for instance ubiquitin-proteasome procedure or lysosomal process, which removes unnec

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